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Publications

2008

2007

20- Zumbuehl, A.*, Ferreira, L.S.*, Kuhn, D., Astashkina, A., Long, L., Yeo, Y., Iaconis, T., Ghannoum, M., Fink, G.R., Langer, R., Kohane, D.S. “Antifungal hydrogels”. Proceedings of the National Academy of Sciences 2007, 104, 12994-12998. *Authors contributed equally.

21- Fuller, J., Zugates, G., Ferreira, L., Ow, H., Nguyen, N., Wiesner, U., Langer, R. “Intercellular delivery of core-shell fluorescent silica nanoparticles”. Biomaterials 2008, 29, 1526-1532.

19- Nijst, C., Joost, J., Karp, J.M., Ferreira, L., Zumbuehl, A., Bettinger, C., Langer, R. “Development of Multifunctional Photocurable Degradable Elastomers”. Biomacromolecules 2007, 8, 3067-3073.

18- Ferreira, L, Gerecht-Nir, S., Shieh, H.F., Watson, N., Rupnick, M, Dallabrida, S, M, Vunjak-Novakovic, G., Robert Langer, R. “Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle-like cells and form vascular networks in vivo”. Circulation Research 2007, 101, 286-294.

17- Gerecht-Nir, S., Burdick, J.A., Ferreira, L.S., Langer, R., Vunjak-Novakovic, G. “Propagation of undifferentiated human embryonic stem cells in 3-dimentional hyaluronic acid networks”. Proceedings of the National Academy of Sciences 2007, 104(27), 11298-11303.

22- Mahdavi A*, Ferreira L*, Sundback C, Nichol JW, Chan EP, Carter JD,Bettinger C, Patanavanich S, Chignozha L, Ben-Joseph E, Galakatos A, Pryor H, Pomerantseva I, Masiakos P, Faquin W, Zumbuehl A, Hong S, Borenstein J, Vacanti J, Langer R, Karp JM. "A biodegradable and biocompatible Gecko-inspired tissue adhesive".  Proceedings of the National Academy of Sciences 2008, 105(7), 2307-2312. *Authors contributed equally.

16- Ferreira, L., Gerecht, S, Fuller, J, Shieh, HF, Vunjak-Novakovic, G, Langer, R. “Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells”. Biomaterials 2007, 28(17), 2706-2717.

15- Ferreira, L.*, Khademhosseini, A.*, Blumling, J, Yeh, J., Karp, J.M., Fukuda, J., Langer, R. “Co-culture of human embryonic stem cells with murine embryonic fibroblasts on microwell-patterned substrates”. Biomaterials 2006, 27, 5968-5977. *Authors contributed equally. .

2006

23- Ferreira  L, Squier T, Park H, Choe H, Kohane DS, Langer R.“Human embryoid bodies containing nano- and micro-particulate delivery vehicles”. Advanced Materials 2008, 20, 2285-2291.

14- Jeffrey M. Karp, Lino S. Ferreira, Ali Khademhosseini, Albert H. Kwon, Judy Y. Yeh, Robert Langer. “Cultivation of human embryonic stem cells without the embryoid body step enhances osteogenesis in vitro”. Stem cells 2006, 24(4), 835-843.

13- Ferreira, L., Figueiredo, M.M., Gil, M.H., Ramos, M.A. “Structural analysis of dextran-based hydrogels obtained chemoenzymatically”, Journal of Biomedical Materials Research: part B (Applied Biomaterials) 2006, 77B:55-64.

12- Maia, J., Ferreira, L., Carvalho, R., Ramos M.A., Gil, M.H. “Synthesis and characterization of new injectable and degradable dextran-based hydrogels.” Polymer 2005, 46, 9604-9614.

2005

11- Ferreira, L., Evangelista M.B., Martins M.C.L., Esteves, J.L., Barbosa, M.A. “Improving the adhesion of poly(ethylene terephthalate) fibers to poly(hydroxyethyl methacrylate) hydrogels by ozone treatment: surface characterization and pull-out tests.” Polymer 2005, 46, 9840-9850.

10- Ferreira, L., Gil, M.H., Cabrita, A.M.S., Dordick, J.S. “Biocatalytic synthesis of highly ordered biocompatible and degradable dextran-based hydrogels”, Biomaterials 2005, 26, 4707-4716.

2004

9- Ferreira, L., Rafael, A., Lamghari, M., Barbosa, M.A., Gil, M.H., Cabrita, A.M.S., Dordick, J.S. “Biocompatibility of  chemoenzymatically derived dextran hydrogels”, Journal of Biomedical Materials Research 2004, 68A, 584-596.

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8- Ferreira, L., Ramos, M.A., Dordick, J.S., Gil, M.H. “Influence of different silica derivatives in the immobilization and stabilization of a Bacillus licheniformis protease (subtilisin Carlsberg)”, Journal of Molecular Catalysis B: Enzymatic 2003, 21, 189-199.

2003

7- Ferreira, L., Ramos, M.A., Gil, M.H., Dordick, J.S. “Exquisite regioselectivity and transesterification activity enhancement of an immobilized Bacillus subtilis protease”. Biotechnology Progress 2002, 18(5), 986-993.

2002

6- Ferreira, L., Kim, D.-Y., Carvalho, R., Geraldes, C.F.G.C., Gil, M.H., Dordick, J.S. “Biocatalytic polytransesterification of inulin with divinyladipate”, Chemistry of Materials 2002, 14(10), 4009-4011.

5- Ferreira, L., Gil M.H., Dordick, J.S. “Enzymatic synthesis of dextran-containing hydrogels”, Biomaterials  2002, 23, 3957-3967.

4- Ferreira, L., Carvalho, R., Gil, M.H., Dordick, J.S. “Enzymatic synthesis of inulin-containing hydrogels”, Biomacromolecules 2002, 3, 333-341.

2001

3- Ferreira, L., Vidal, M.M., Gil, M.H. “Design of a drug-delivery system based on polyacrylamide hydrogels. Evaluation of structural properties”, Chem. Educator 2001, 6, 100-103.

2- Ferreira, L., Vidal, M.M., Gil, M.H. “Evaluation of poly(2-hydroxyethyl methacrylate) gels as drug delivery systems at different pH values”, International Journal of Pharmaceutics 2000, 194(2), 169-180.

2000

1- Ferreira, L., Vidal, M.M., Geraldes, C.F.G.C., Gil, M.H. "Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate”, Carbohydrate Polymers 2000, 41(1), 15-24.

Chapters in books

1-Gil M.H., Duarte, M.G., Ferreira, L., Geraldes, C.F.G. “Polymeric Biomaterials”. In: Polymer Chemistry, Eds: Melo, J.S.S., Moreno, M.J., Burrows, H.D., Gil, M.H. Coimbra University Press, Coimbra, 2004, p. 641-664.

2- Ferreira*, L., Khademhosseini*, A., Karp*, J.M., Gerecht-Nir*, S., Vunjak-Novakovic, G., Langer, R. “Embryonic stem cells as a cell source for tissue engineering”. In: “Principles of Tissue Engineering- 3^rd edition”. Editors: Lanza, R., Langer, R., Vacanti, J.P. Elsevier/Academic Press, 2006. (*Authors contributed equally).

3- Luo, Y., Ferreira, L., Langer, R. “Three-dimensional scaffolds”. In: “Principles of Tissue Engineering- 3^rd edition”. Editors: Lanza, R., Langer, R., Vacanti, J.P. Elsevier/Academic Press, 2006.

4- Karp, J. M., Mahdavi, A., Ferreira, L.S., Khademhosseini, A., Langer, R. “In vitro differentiation of human embryonic stem cells along osteogenic pathways”. In: “Human Embryonic Stem Cells: A Practical Handbook”, edited by: Sullivan S, Cowan C, Eggan K. John Wiley & Sons, Ltd., 2006.

5- Ferreira, L.*, Gerecht, S.*, Langer, R. “Vascular differentiation of human embryonic stem cells in bioactive hydrogel scaffolds”. In : “Human embryonic stem cells- methods and protocols”. Editors: Turksen, Walker. Humana Press 2008 (Authors contributed equally).

6- Spelke, D.P., Ortmann, D., Khademhosseini, A., Ferreira, L., Karp, J.M.”Method for EB formation- the microwell approach” In: “Embryonic stem cell therapy for osteodegenerative diseases”, Series Methods in Molecular Biology, Editor: Nieden, Nicole. Humana Press 2008. 

7– Sarkar D, Zhao W, Schaefer S, Ankrum JA, Teo GS, Pereira MN, Ferreira L, Karp JM. “Overview of tissue engineering concepts and applications”, In: Biomaterials Science: an introduction  to materials in medicine”, 3rd edition, Editors: Ratner, BD, Hoffman, AS, Schoen, FJ, Lemons, JE. Academic Press 2009.

8– Kraehenbuehl TP, Aday S, Ferreira LS. “Scaffolding for three-dimensional embryonic vasculogenesis”, In: “Biophysical regulation of vascular differentiation and assembly”, Editor: Sharon Gerecht. Springer 2010.

9– Cho, WK, Pereira, MJMN, Lang, N, Lee, K, Mureli, S, Ferreira, L, Langer, RS, Karp, JM. “Gecko-inspired tape-based adhesives”, In: “Novel Biomaterials for wound closure”. Editor: Pan Stanford Publishing 2010.

10– Valente, AXCN*, Sousa, JAB, Outeiro, TF, Ferreira,L. “A stem-cell ageing hypothesis on the origin of Parkinson´s disease”. In “Science and Engineering in high-throughput biology including a theory on Parkinson´s disease. Editor: André X.C.N. Valente. Lulu 2011. *Coresponding author.

 

 

 

Patents

1-Karp, J.M., Ferreira, L.S., Khademhosseini, A., Langer, R.S. “Amplification of specific cell populations from human embryonic stem cells”. WO2007022348, 2007 .

2- Ferreira, L.S., Gerecht-Nir, S., Vunjak-Novakovic, G., Langer, R.S. “Formation of vascular networks using human embryonic stem cells”. WO2007140340, 2007.

3- Nijst, C., Karp, J.M., Joost, J., Ferreira, L., Zumbuehl, A., Bettinger, C., Langer, R. “Development of Multifunctional Photocurable Degradable Elastomers”. WO 2007082304 and WO 2007082305, 2007.

4- Christopher Loose, William Shannan O´Shaughnessy, Lino Ferreira, Andreas Zumbuehl, Robert Langer, Gregory Stephanopolous. “Medical devices and coatings with non-leaching bioactive peptides”. WO 2007095393, 2007.

5- Zumbuehl, A., Ferreira, L.S., Kohane, D.S., Fink, G.R., Langer, R.S. “Coating of devices with gel, foam, film, particle or compn, comprising a polymer solvent and effector compounds, and their use for preventing infection and treatment of diseases. WO 2008005297.

6- Ferreira, L., Kohane, D., Langer, R.“Human embryoid bodies containing nano- and micro-particulate delivery vehicles“. WO 2009100128, 2009 .

7- Lino Ferreira, Alborz Mahdavi, Cathryn Sundback, David J. D. Carter, Chris Bettinger, Andreas Zumbuehl, Jeff Borenstein, Joseph Vacanti,  Robert Langer, Jeffrey M. Karp. “A biodegradable and biocompatible Gecko-inspired tissue adhesive”. WO 2009067482, 2009.

8- Lino Ferreira, Cristiana Paulo. “ Antimicrobial nanoparticle conjugate”. Pending Patent, 2010.

9- Lino Ferreira, Dora Pedroso. “Method for improving the survival, vascular differentiation and wound healing potential of stem cells by co-culturing with endothelial cells in a biomimetic gel”. Pending Patent, 2010.

10- Maia, J, Santos, T, Malva, JO, Bernardino, L*, Ferreira, L*. “Nanoparticles to control stem cells”. Pending Patent, 2010.

 

 

24- Ferreira  L*, Karp JM, Nobre L, Langer R*. “New opportunities: the use of nanotechnologies to manipulate and track stem cells”. Cell Stem Cell 2008, 3(2), 136-146. *Corresponding authors.

2009

26- Ferreira  LS*, Zumbuehl A*. “Non-leaching surfaces capable of killing microorganisms on contact”. Journal of Materials Chemistry 2009, 19, 7796-7806. *Corresponding authors.

25– Kraehenbuehl TP, Ferreira LS, Zammaretti P, Hubbell JA, Langer R. “Cell-responsive hydrogel for encapsulation of vascular cells”. Biomaterials 2009, 30(26), 4318-4324.

27- Ferreira  LS. “Nanoparticles as tools to study and control stem cells”. Journal of Cellular Biochemistry 2009, 108(4), 746-752.

2010

28– Levenberg, S*, Ferreira  LS*, Chen-Konak, L, Kraehenbuehl, TP, Langer, R. “Isolation, differentiation, and characterization of vascular cells derived from human embryonic stem cells”. Nature Protocols 2010, 5, 1115-1126. *Authors contributed equally.

Biomaterials and Stem Cell-Based Therapeutics

29– Paulo, C, Vidal, M, Ferreira, LS. ”Antifungal nanoparticles and surfaces”. Biomacromolecules 2010, 11, 2810-2817.

30– Ferreira, L*,  Pedroso, DCS, Vazão, H, Gomes, RSM. “Stem cell-based therapies for heart regeneration: what did the bench teach us?” Cardiovascular & Haematological Disorders-Drug Targets 2010, 10, 173-185. *Corresponding author. 

31– Maia, J,  Santos, T, Aday, S, Agasse, F, Cortes, L, Malva, JO, Bernardino, L, Ferreira, L. “Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles. ACS Nano 2011, 5(1), 97-106. Authors contributed equally. L F and LB are corresponding authors.

2011

33– Kraehenbuehl, T.P., Ferreira, L.S.*, Hayward, A.M., Nahrendorf, M., Vlies, A.J., Vasile, E., Weissleder, R., Langer, R.*, Hubbell, J.A.* “Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction”. Biomaterials 2011, 32(4), 1102-1109. *Corresponding authors. 

32– Pedroso, DCS, Tellechea, A, Moura, L, Fidalgo-Carvalho, I, Duarte, J, Carvalho, E, Ferreira, L. “Improved survival, vascular differentiation and wound healing potential of umbilical cord stem cells co-cultured with endothelial cells”. PLoS One 2011, 6(1):e16114.

34– Vazão, H, Pires das Neves, R, Grâos, M, Ferreira, L. “Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells”. PLoS One 2011, 6(3): e17771.  

35– Nunes-Pereira, MJ, Fidalgo-Carvalho, I, Karp, JM*, Ferreira, LS*. “Sensing the cardiac environment: exploiting cues for regeneration”. Journal of Cardiovascular Translational Research 2011 (in press). *Corresponding authors

36– Kraehenbuehl, TP, Langer*,R, Ferreira, LS*. “Biomaterials for the self-renewal and differentiation of human pluripotent stem cells”. Nature Methods 2011 (in press). *Corresponding author.

37– Bernardino, L, Eiriz, MF, Santos, T, Xapelli, S, Grade, S, Rosa, A, Cortes, L, Ferreira, R, Bragança, J, Agasse, F, Ferreira, L, Malva, JO. “Histamine, a proneurogenic factor on the subventricualr zone: a new approach for brain repair”. (Submitted)

38– Maia, J*, Vazão, H*, Pedroso, DCS*, Jesus, C, Brito, RMM, Gil, MH, Ferreira, L. “Dual pro-angiogenic therapy based on the release of VEGF165 and endothelial cells derived from umbilical cord stem cells in a hybrid network”. (Submitted) *Authors contributed equally.

39– Paulo, CSO*, Pires das Neves, R*, Ferreira, LS. “Nanoparticles for intracellular-targeted drug delivery”. Nanotechnology (in press). *Authors contributed equally.